Sertraline, an Anti-Depressant, May Change Brain Structures Differently in Depressed and Non-Depressed Individuals

Very interesting animal study.

From their own website;

Antidepressants are usually prescribed for individuals suffering from depression, which work by changing one or more of the neurotransmitters in the brain. Selective Serotonin Reuptake Inhibitors (SSRIs) are one such anti-depressant medication and inhibit the reabsorption of serotonin, thereby increasing the levels of this neurotransmitter. The shift in serotonin levels enables the brain cells to transmit messages better, and as a consequence, improve mood… Since Sertraline is prescribed for both depression and non-mood disorders, such as anorexia, bulimia, hot flashes, and post-traumatic stress disorder (PTSD), the current study was conducted to throw light on the effect of Sertraline on the brains of depressed, as well as non-depressed subjects… The results show:
In depressed monkeys, Sertraline increased the volume of the anterior cingulate cortex in the brain (the anterior cingulate cortex is involved in memory, cognition, learning, modulation of emotional behavior, spatial navigation, etc.).
Sertraline decreased the volume of the anterior cingulate cortex, as well as the hippocampus in non-depressed subjects (The hippocampal region is associated with memory and learning).

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